Bupropion Dosage: Simple Guide to Getting the Right Amount

If you’ve been prescribed bupropion (brand name Wellbutrin), you probably wonder how much to take and when to change the dose. The good news is the dosing schedule is straightforward, but it does vary depending on why you’re using the drug and which formulation you have.

Standard doses for depression and smoking cessation

For adults treating major depressive disorder, doctors usually start with 150 mg once daily on the first three days. After that, the dose jumps to 150 mg twice a day (total 300 mg). If you’re fine with the side‑effects, the maximum approved dose is 450 mg per day, split into two doses.

When bupropion is used to help quit smoking (the brand Zyban), the routine is similar: 150 mg once daily for three days, then 150 mg twice daily. Some people stay on the 300 mg total, while others can increase to 450 mg if they need more craving control.

Extended‑release (SR) and XL tablets

SR (sustained‑release) tablets are taken once a day, usually in the morning. The common starting dose is 150 mg SR. After three days you can rise to 300 mg SR. The max for SR is 400 mg per day, split into two 200 mg pills if needed.

XL (extra‑long) tablets are also once‑daily but come in 150 mg and 300 mg strengths. Doctors often start with the 150 mg XL and may increase to 300 mg XL after a week, depending on response and tolerance.

Because SR and XL release the drug more slowly, they tend to cause fewer jittery feelings and insomnia. If you notice those side‑effects, taking the medication earlier in the day or switching to an SR/XL form can help.

Special groups: kids, seniors, and kidney issues

Kids under 18 are not approved for bupropion for depression, but it can be used for ADHD in some cases. Doses are weight‑based and must be set by a pediatric specialist.

Older adults (65+) often start at the lower end – 150 mg once daily – because they process the drug more slowly. Monitoring for seizures is key, especially if the dose climbs above 300 mg.

If you have moderate to severe kidney impairment, the dose should be reduced by half. Your doctor will calculate the exact amount based on your lab results.

How to adjust and what to watch for

Never double a missed dose. If you miss a pill, take it as soon as you remember, unless it’s close to the next scheduled dose – then just skip it. Jumping from 150 mg to 300 mg too fast raises the risk of seizures.

Common side‑effects include dry mouth, insomnia, and mild headaches. If you get a severe rash, trouble breathing, or a seizure, call emergency services right away.

When you’re buying bupropion online, make sure the pharmacy is licensed and requires a prescription. Look for sites that offer price guarantees and clear return policies – for example, the “Buy Generic Wellbutrin (Bupropion) Online in Australia” post on our site explains how to spot legit sellers.

In summary, start low, stay consistent, and let your doctor guide any dose changes. With the right amount, bupropion can lift mood, curb nicotine cravings, and keep side‑effects manageable.