GERD Medication: What Works, What to Avoid, and How to Choose

When you’re dealing with constant heartburn or that sour taste in your throat, you’re not just uncomfortable—you’re dealing with GERD medication, a category of drugs designed to reduce stomach acid and heal damage from chronic acid reflux. Also known as acid reflux treatment, these medications are among the most commonly prescribed in the U.S., with millions relying on them daily to get through the day. But not all GERD meds are the same. Some work fast, others take weeks. Some help with symptoms, others actually heal your esophagus. And not all are safe for long-term use.

The two main types you’ll see are proton pump inhibitors, strong acid blockers that shut down the stomach’s acid production at its source. Also known as PPIs, they include drugs like omeprazole, esomeprazole, and lansoprazole. Then there are H2 blockers, a less powerful but faster-acting option that reduces acid by blocking histamine receptors. These include famotidine and ranitidine (though the latter was pulled from many markets due to safety concerns). PPIs are usually the first line for moderate to severe GERD. H2 blockers are often used for mild cases or as a backup when PPIs aren’t enough—or when you need quick relief before a meal.

But here’s the thing: long-term use of PPIs can lead to real problems. Studies show links to nutrient deficiencies (like magnesium and B12), increased risk of bone fractures, and even kidney issues. That’s why many people end up switching to alternatives—lifestyle changes, antacids, or even newer treatments like vonoprazan. And if you’ve tried one GERD medication and it didn’t work, it doesn’t mean you’re out of options. Different people respond differently. What works for your neighbor might do nothing for you.

Below, you’ll find real comparisons of medications, side effects, costs, and what actually works based on user experiences and clinical data. No marketing fluff. Just what you need to know to talk to your doctor with confidence—or decide if you even need a pill at all.